|
Title |
|
Three dimensional modeling of N-terminal region of galanin and its interaction with the galanin receptor
|
|
Authors |
Marimuthu Parthiban1 and Piramanayagam Shanmughavel1, *
|
|
|
Affiliation |
1Department of Bioinformatics, Bharathiar University, Coimbatore - 641046, India
|
|
| Phone |
91 422 2422655 |
|
| Fax |
91 422 2422387 |
|
|
|
shanvel_99@yahoo.com; * Corresponding author |
|
|
Article Type |
Hypothesis |
|
|
Date |
received August 13, 2007; accepted November 09, 2007; published online December 05, 2007 |
|
|
Abstract |
The neuropeptide galanin comes under the powerful and versatile modulators of classical neurotransmitters and is present in brain tissues, which are intimately involved in epileptogenesis. It acts as appealing targets for studying basic mechanisms of seizure initiation and arrest, and for the development of novel approaches for various neurodegenerative diseases. Galanin is widely distributed in the mammalian brain which controls various processes such as sensation of pain, learning, feeding, sexual behaviour, carcinogenesis, pathophysiology of neuroendocrine tumors and others. The function of galanin can be exploited through its interaction with three G-protein coupled receptors subtypes such as GalR1, GalR2 and GalR3. The N-terminal region of galanin comprises about highly conserved 15 amino acid residues, which act as the crucial region for agonist-receptor binding. We have constructed a theoretical structural model for the N-terminal region of galanin from Homo sapiens by homology modeling. The stereochemistry of the model was checked using PROCHECK. The functionally conserved regions were identified by surface mapping of phylogenetic information generated by online web algorithm ConSurf. The docking studies on the pharmacologically important galanin receptors with the theoretical model of N-terminal region of galanin predicted crucial residues for binding which would be useful in the development of novel leads for neurodegenerative disorders.
|
|
|
Keywords
|
binding site; agonist- receptor; docking; homology modeling
|
|
|
Citation |
Parthiban & Shanmughavel, Bioinformation 2(3): 119-125 (2007)
|
|
|
Edited by |
R. Sowdhamini |
|
|
ISSN |
0973-2063
|
|
|
Publisher |
|
|
|
License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |