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Title

Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum

 

Authors

Venkata Rao Dodaghatta Krishna Rao1*, Rallapalli Ramanjeneyulu1, Dowlathabad Muralidhara Rao2* and Chitta Suresh Kumar3

 

Affiliation

1Department of Microbiology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India; 2Department of Biotechnology, Bioinformatics Laboratory, Sri Krishnadevaraya University, Anantapur; 3Department of Biochemistry, Sri Krishnadevaraya University, Anantapur.

 

E-mail*

muralidhararao@yahoo.co.in; * Corresponding author

 

Article Type

  

Views & Proposal

 

Date

  

received December 28, 2005; revised January 23, 2006; accepted January 24, 2006; published online January 24, 2006

 

Abstract

  

Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema pallidum. Comparative genome analysis shows the absence of its sequence homolog in eukaryotes. The structure of class I lysyl tRNA synthetase from Treponema pallidum is unknown and the difficulties in the in vitro culturing of Treponema makes it non-trivial. We used the structural template of class I lysyl tRNA synthetase from the archaea Pyrococcus horikoshii for modeling the Treponema pallidum lysyl tRNA synthetase structure. Thus, we propose the usefulness of the modeled class I lysyl tRNA synthetase for the design of suitable inhibitors towards the treatment of syphilis.

 

Keywords

  

Treponema pallidum; lysyl tRNA synthetase; modeller; syphilis; comparative modeling

 

Citation

  

Rao et al., Bioinformation 1(3): 81-82, (2006)

 

Edited by

  

N. Gautham

 

ISSN

 

0973-2063

Publisher

  

Biomedical Informatics

 

License

  

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.