Title

A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culex species from diverse geographical locations

Authors

Ryavarapu Bhargavi¹, Siddharth Vishwakarma² and Upadhyayula Suryanarayana Murty¹*

Affiliation

¹Bioinformatics Group, Biology Division, Indian Institute of Chemical Technology, Hyderabad, India; ²Department of P.G. Studies and Research in Biological Sciences, RDVV, Jabalpur, India.  

E-mail*

murty_usn @yahoo.com; * Corresponding author

Fax

+91-40-27193227

Article Type

Hypothesis

Date

received August 15, 2005; revised September 19, 2005; accepted October 3, 2005; published online October 5, 2005

Abstract

In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous domains. Four species namely C. vishnui, C. annulus, C. pipiens, C. quiquefasciatus showed high sequence (98-100%) and RNA secondary structure similarity. The ITS2 similarity among different species is high despite their varying geographical locations. Several common features of secondary structure are shared among these species, with some of them supported by compensatory changes, suggesting the significant role by ITS2 as an RNA domain during ribosome biogenesis.

Keywords

Culex; ITS2; secondary structure; geographical locations; ribosome biogenesis

Citation

Bhargavi et al., Bioinformation 1(2): 52-55 (2005)

Edited by

Paul Shapshak

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.