Title

Micro RNA210 expression in pregnancies with preeclampsia

Authors

Shali Paremmal¹, Nidhi Sharma², Rama Devi³ & Keerti gopi⁴*

Affiliation

¹Department of Anatomy, Government Medical College Mahabubnagar, Telangana; ²Department of obstetrics and gynaecology, Saveetha Medical College, Tamilnadu; ³Department of Microbiology, Government Medical College Mahabubnagar, Telangana; ⁴Department of Biochemistry, Government Medical College Mahabubnagar, Telangana; India: *Corresponding author.

Email

Shali Paremmal - E-mail: shalip90@gmail.com

Nidhi Sharma - E-mail: drbonuramkumar@gmail.com

Rama Devi - E-mail: kollabathulla.rama@gmail.com

Keerti Gopi - E-mail: keerthi.gopi77@gmail.com

Article Type

Research Article

Date

Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023

Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a  regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia.

Keywords

Preeclampsia, hypoxia, microRNA 210

Citation

Paremmal et al. Bioinformation 19(3): 319-322 (2023)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.