Title
Phytochemical cocktail of Asanadi gana extract in the management of diabetes
Authors
Rekha Kumari Dulala1, Manikandan Balraj2, Sangeeta Chandrashekar3, Muninathan N4, Nithiya Rajapandiyan5, Ramya Badrachalam6 & Vadivel Mani1*
Affiliation
1Department of Biochemistry, Konaseema Institute of Medical sciences and research foundation, Amalapuram, East Godavari Dt-533201, Andhra Pradesh, India; 2Department of Physiology, Konaseema Institute of Medical sciences and research foundation, Amalapuram, East Godavari Dt-533201, Andhra Pradesh, India; 3Department of Physiology, Bharath Institute of Higher Education and Research, Chennai-600073, Tamilnadu, India; 4Central Research Laboratory, Meenakshi Medical College and Hospital, Kanchipuram-631552, Tamilnadu, India; 5Department of Physiology, Arunai Medical College & Hospital, Tiruvanamallai-606603, Tamilnadu, India; 6Department of Biochemistry, Sri Manakula Vinayagar Medical College and Hospital, Puducherry - 605107, Tamil Nadu, India; *Corresponding author
Vadivel Mani – E-mail: Velvdm.vel5@gmail.com
Rekha Kumari Dulala –Email: rekha.dulala@gmail.com
Manikandan Balraj –Email: ayurveda@gmail.com
Sangeeta Chandrashekar –Email: gsangeetakv@gmail.com
Muninathan N –Email: muninathanpappaiya@gmail.com
Nithiya Rajapandiyan –Email: nithuran@gmail.com
Ramya Badrachalam- Email: drramya830@gmail.com
Article Type
Research Article
Date
Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023
Abstract
It is of interest to investigate that the phytochemical analysis, in-vitro antioxidant potential and glycosidase inhibitory potential of Asanadi gana a polyherbal formulation. Asanadi gana is a classical Ayurvedic polyherbal formulation, markedly used for alleviation of Prameha and medodosha, which correlates in many ways with obesity, metabolic syndrome, and diabetes mellitus (madhumeha). The phytochemical constituents, total phenolic, total flavonoids, total tannin content, total antioxidant capacity, total reducing power, and free radical scavenging activity of the polyherbal formulation extracts were determined. Comparing it to the common medication Acarbose, its inhibitory impact against the digestive enzymes α-amylase and α-glucosidase was also examined. The formulation showed the presence of major constituents such as terpenoids, triterpenoids, sterols, flavonoids, tannins, phenolic, saponins, alkaloids and Glycosides. The ethanol extract had high phenolic content and flavonoid content, whereas the aqueous extract had more tannin content (181 ± 5.5µg/mg), (132 ± 5.50 µg/mg), (22± 1.6 µg/mg respectively. we conclude that the extracts of ayurvedic polyherbal formulations, particularly ethanol extract are a potential source of natural antioxidants and remarkable glycosidase inhibitory activity. Hence, Asanadi gana has the potential to be a safe and effective natural treatment for the delay or prevention of diabetic complications.
Keywords
Asanadi gana, Antioxidant, Organic radicals scavenging activity
Citation
Dulala et al. Bioinformation 19(3): 299-306 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
