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Title

Phytochemical screening and anti-obesity, anti- diabetic and anti-oxidant properties of Scoparia dulcis leaf decoction (crude)

 

Authors

Arulandhu Clara Mary1, Christopher Ireen1,2,, PeriyasamyVijayalakshmi1,2, Sabapathy Indhu1,2,,  Sekar Divyabharathi 3,  Kulandaisamy Suregka Felix 4, Viyagulasamy Daisyrani5 & Manikkam Rajalakshmi1,2,3*

 

Affiliation

1Department of Biotechnology and Bioinformatics, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 2DBT-BIF Centre, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 3Department of Zoology, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 4Department of Business Administration, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 5Department of  Social Work, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; *Corresponding author

 

Email

A. Clara Mary E-mail: claramary@hcctrichy.ac.in

C. Ireen - E-mail:  ireen@hcctrichy.ac.in

P. Vijayalakshmi - E-mail: vijayalakshmi01@hcctrichy.ac.in

S. Indhu - E-mail: sabaindhu2010@gmail.com

S. Divyabharath - E-mail: mdrajimd@gmail.com

M. Suregka - E-mail: suregkafelix@hcctrichy.ac.in

V. Daisyrani - E-mail: daisyrani@hcctrichy.ac.in.

M. Rajalakshmi - E-mail: rajalakshmi@hcctrichy.ac.in & mdraji@gmail.com

 

Article Type

Research Article

 

Date

Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023

 

Abstract

Due to their rising prevalence, diabetes and obesity were both classified as epidemics by the World Health Organization.The natural leaf essence of Scoparia dulcis (S. dulcis), is used as herbal remedy for diabetes and obesity worldwide. However, the objective of the current research was to examine the effects of consuming commercially available S. dulcis porridge on both diabetes and obesity. The S. dulcis plants were collected and the essence was prepared in a traditional way. Phytochemical screening was carried out to identify the secondary metabolites present in the essence. The GC-MS analysis was carried out to identify the bioactive compounds present in the extracts.  In order to understand the molecular interaction of identified compounds with selected target proteins from anti-diabetic, anti-oxidant, anti-obesity molecular docking studies was carried out. Results of this docking studies confirmed that identified compounds showed the strong interaction with all the selected target protein. Further experimental analysis is needed to confirm this activity.

 

Keywords

Diabetes, Scoparia dulcis, phytocompounds & molecular docking.

 

Citation

     Clara Mary et al. Bioinformation 19(3): 238-243 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.