Title

Antimicrobial evaluation and molecular docking studies of the combined ethanolic extract of Mollugo cerviana and Mukia maderspatana

Authors

F. Sherin Rebecca¹, V. Vidhya Lakshmi¹, M. Jeyashree², A. Elavarasi² & Rajamanickam Ponnivedha²*

Affiliation

¹PG and Research Centre of Zoology, Jayaraj Annapackiam College for Women (Autonomous) Periyakulam, Theni, Tamilnadu, India; ²DBT-BIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College, Affiliated to Bharathidasan University, Tiruchirappalli-620 002, Tamil Nadu, India; *Corresponding author

Email

R. Pon Nivedha - Fax No: 0431-2713312; E-mail: nivedharajamanickam@gmail.com

Sherin Rebecca F- E-mail: sherinborgia@gmail.com

V. Vidhya Lakshmi - E-mail: vidhya2018v@gmail.com

M. Jeyashree - E-mail: jeyashreemahavasudevan03@gmail.com

A. Elavarasi - E-mail: elavarasiamirtham4@gmail.com

Article Type

Research Article

Date

Received February 1, 2023; Revised February 28, 2023; Accepted February 28, 2023, Published February 28, 2023

Medicinal plants are considered to be the source of richness in Traditional Medicine. The chosen plants Mollugocerviana (L.) and Mukiamaderas patina. (L.)   are commonly used to treat various ailments in traditional medicine. In the present study these two Plants were extracted with Ethanol and were subjected to Phytochemical Analysis to confirm the presence of different Phytochemicals. After phytochemical analysis the antimicrobial efficiency of the Plant extracts were checked against different microbial pathogens. The results confirm that the combined extract of both the plants shows potent activity against selected pathogenic strains. The results clearly indicate that the activity is in a dose dependent manner which is defined as higher the concentration higher the activity. GC–MS analysis of the extracts showed the presence of Ergost-7-en-3-ol. This ligand was docked with TyRs protein of S. aureus to understand the interactions and predict the affinity and the activity of the potent bioactive molecules. It shows promising interaction with respect to binding poses of interacted complex. From the current study it is proved that the chosen plants are highly loaded with nutrients and can be used as a drug target in future. Further studies are required to confirm the efficiency of the plant extracts.

Keywords

Antimicrobial, molecular, Mollugo cerviana and Mukia maderspatana

Citation

Rebecca et al. Bioinformation 19(2): 190-195 (2023)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.