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Title

Molecular docking analysis of Indole based diaza-sulphonamides with JAK-3 protein

 

Authors

Manya Nautiyal1, Kavitha Sankaran*1, Surya Sekaran2, Gayathri Rengasamy1, Vishnu Priya Veeraraghavan1 & Rajalakshmanan Eswaramoorthy*2

 

Affiliation

1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077; 2Department of Biomaterials (Green lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai-600077; Corresponding author

 

Email

Manya Nautiyal E-mail:152101057.sdc@saveetha.com

Kavitha Sankaran - E-mail:kavithas.sdc@saveetha.com

Surya Sekaran - E-mail:suryas.sdc@saveetha.com

Gayathri Rengasamy - E-mail:gayathri.sdc@saveetha.com

Vishnu Priya Veeraraghavan - E-mail:vishnupriya@saveetha.com

Rajalakshmanan Eswaramoorthy - E-mail:rajalakshmanane.sdc@saveetha.com

 

Article Type

Research Article

 

Date

Received January 1, 2023; Revised January 30, 2023; Accepted January 31, 2023, Published January 31, 2023

 

Abstract

JAK-3 gene is a part of an important signalling pathway in oral cancer. Therefore, it is of interest to evaluate the inhibitory properties of new indole based diaza-sulphonamides compounds against JAK3 gene. Molecular docking analysis showed that among the selected compounds (1-9), the compounds 1-4 turned out to be the most potentially capable ones to be used as ant-cancer drugs. Also, they are proved to be non-toxic.

 

Keywords

Oxadiazoles, indole, diaza-sulphonamides, anti-cancer, JAK-3

 

Citation

Nautiyal et al. Bioinformation 19(1): 74-78 (2023)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.