Title
In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
Authors
Abraham Sabu1, J. Selvaraj2, R. Gayatridevi1 & E. Dilipan1*
Affiliation
1Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India. 2CoMMand, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India; *Corresponding author
Abraham Sabu – E-mail: abrahamsabuputhu@gmail.com
J. Selvaraj – E-mail: selvaraj@saveetha.com
R. Gayatridevi – E-mail: gayatridevi@saveetha.com
E. Dilipan – E-mail: dilipanev@gmail.com
Article Type
Research Article
Date
Received January 1, 2023; Revised January 30, 2023; Accepted January 31, 2023, Published January 31, 2023
Abstract
The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine.
Keywords
Rauwolfia tetraphylla, breast cancer, cytotoxicity, gene expression, TGF and Bcl1 gene.
Citation
Sabu et al. Bioinformation 19(1): 43-47 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
