Title
Linking inflammatory mediators and indicators of insulin resistance in anthropometry specified type 2 diabetic males
Authors
Venkata Ramesh Bonam, Abu Raghavan Srinivasan & Daniel Devaprasad Manoj
Affiliation
1Department of Biochemistry, Apollo Institute of Medical Sciences and Research (AIMSR), Chittor campus, Murukambattu, Chittoor 517127 Andhra Pradesh, India; 2Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth (SBV), SBV Campus, Pillaiyarkuppam, Pondicherry - 607 402, India; 3Department of General Medicine, Apollo Institute of Medical Sciences and Research (AIMSR), Chittor campus, Murukambattu, Chittoor 517127 Andhra Pradesh, India
Venkata Ramesh Bonam – E-mail: bonam8ramesh@gmail.com
Abu Raghavan Srinivasan – E-mail: raghavan.drvars2000@gmail.com; Phone: +91 9994455627; Fax: 0413 2615457
Daniel Devaprasad Manoj – E-mail: drdanieldmanoj@gmail.com
Article Type
Research Article
Date
Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022
Abstract
Inflammation associated with insulin resistance is a risk factor in the development of complications in Type 2 diabetes mellitus (T2DM). The study was conducted to assess the relationship between inflammatory mediators and insulin resistance, independent of lipid profile in anthropometry specified male Type 2 diabetics. 180 males having T2DM for more than 5yrs and on diabetic medication were chosen for the study and categorized into obese and overweight. Patients with thyroid or other endocrine disorders, kidney, muscle, liver, systemic, and inflammatory diseases were excluded from the study. Blood glucose, glycated hemoglobin, plasma insulin, and the inflammatory biomarkers namely hs-CRP, ferritin, haptoglobin, and adiponectin were evaluated. HOMA-IR and QUICKI were computed to assess insulin resistance. The study demonstrated significant changes in adiponectin and hsCRP in obese and overweight T2DM. However, Ferritin and Haptoglobin were insignificant. The entire biochemical study was carried out to demonstrate lipid profile independent associations. The significant insulin resistance associated with a substantial increase in hs-CRP levels and a pronounced decrease in the adiponectin levels suggests impending diabetic complications in anthropometry specified male T2DM. This could promote the use of personalised medicine to regulate levels of hs-CRP or to improve the secretion of adiponectin thereby countering insulin resistance in T2DM, independent of the lipid profile which is the novelty of our study.
Keywords
T2DM, insulin resistance, inflammation, male
Citation
Bonam et al. Bioinformation 18(10): 998-1004 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
