Title
Intra-articular platelet-rich plasma injection versus hydrocortisone with local anesthetic injections for temporo mandibular disorders
Authors
Jayant Prakash1, Dhaniram Talukder2, Krunal Desai3, Tarun K Singh*4, Reena Bagde5, Gagandeep S Randhawa6, Shambhavi Jha7 & Kapil Paiwal8
Affiliation
1Department of Dentistry, Sadar Hospital, Muzaaffarpur-842001, Bihar, India; 2Department of Prosthodontics and Crown and Bridge, DJ college of dental sciences and research, Modinagar, U.P, India; 3Department of Dentistry, New York University College of Dentistry Class of 2012; 4Department of Dentistry, AIIMS, Bathinda, India; 5Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth Deemed to be University Dental college and Hospital, Sector 7CBD Belapur, Navi Mumbai, 400614, India; 6Department of Oral and Maxillofacial Surgery, Ahmedabad Dental College and Hospital, Ahmedabad, India; 7New Horizon Dental College and Research Institute, Sakri, Bilaspur (C. G) 495001, India; 8Department of Oral Pathology and Microbiology, Daswani Dental College & Research Center, Kota, India; *Corresponding author; Communicated by Vini Mehta – E-mail: vinip.mehta@gmail.com
Jayant Prakash - E-mail: jay.aryan13@gmail.com (+91 9000317931)
Dhaniram Talukder - E-mail: dhaniramtlkdr@gmail.com (+91 6901712312)
Krunal Desai - E-mail: drkjdesai30684@gmail.com (+1(732)599-8734)
Tarun K Singh - E-mail: drtarunkumarsingh@gmail.com (+91 9560627466)
Reena Bagde - E-mail: drreenaingole@gmail.com (+91 9702295199)
Gagandeep S Randhawa - E-mail: randhawa@yahoo.com (+91 9669051622)
Shambhavi Jha - E-mail: shambhavijha25@gmail.com (+91 9771676306)
Kapil Paiwal - E-mail: drpaiwal@gmail.com (+1(201)273-1982)
Vini Mehta – E-mail: vinip.mehta@gmail.com
Article Type
Research Article
Date
Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022
Abstract
Disorders of temporomandibular joint (TMDs) are characterised by a variety of symptoms, including discomfort in the orofacial region, muscle tenderness, restricted jaw motion and noise at the joint. Additional neurological symptoms such as headaches, vertigo, heaviness, and altered vision may also coexist with TMDs. Because prostaglandin production is a critical mediator of inflammatory reaction and is inhibited by corticosteroids, they have anti-inflammatory effects. Platelet rich plasma popularly considered as PRP is a concentration of platelets and related growth factors that may have therapeutic effects by attracting, promoting, and differentiating cells as well as redesigning tissue. 64 joints totaling 40 individuals with temporomandibular joint problems were split into two categories (Category A and Category B). PRP was applied to category A's (36 joints of 20 patients) joints, while Group B's joints received hydrocortisone combined with local anaesthetic (28 joints of 20 patients). Patients were evaluated for tenderness, , maximum inter incisal opening (MIO) and clicking sound at TMJ prior to and following treatment at intervals of one week, one month and 6 months of the first week and third month. When there was comparison of outcomes in study participants receiving injections of platelet rich plasma and study participants receiving injections of hydrocortisone with local anesthetic then it was found that although both type of study participants got reduction in pain, increased opening of mouth and reduction in clicking sound however the difference between two groups was not significant statistically. There was no statistically significant difference between injections of platelet rich plasma and hydrocortisone with local anesthetic solution regarding outcomes in disorders of temporomandibular joint, however the results were slightly better in study participants receiving platelet rich plasma injections. This study demonstrated that while treating patients with TMJ issues, local anaesthesia combined with hydrocortisone as well as intra-articular injection of PRP help in reduction in pain, increase mouth opening, and minimize joint sound. Additionally, it was discovered that intra-articular injection of PRP was more successful in treating patients in this trial than local anaesthetic combined with hydrocortisone.
Keywords
Hydrocortisone with local anesthetic, Intra-articular injection, platelet-rich plasma injection, temporomandibular disorders
Citation
Prakash et al. Bioinformation 18(10): 991-997 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
