Title
Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets
Authors
Ksh. Sangeeta Devi1, M. Damayanti Devi1, N. Chetan Das1, D. Velmurugan2*, N. Rajen Singh1,*
Affiliation
1Manipur University, Manipur, India; 2AMET University, Kanathur, ECR road, Chennai, Tamilnadu, India; *Corresponding authors
D Velmurugan - E-mail: velmurugan@ametuniv.ac.in
N. Rajen Singh – E-mail: nongmaithemnr@rediffmail.com
Article Type
Research Article
Date
Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022
Abstract
Hedychium rubrum, a traditional medicinal plant of Manipur belonging to the family Zingeberaceae was screened for its biological activity. The methanolic extract of its rhizome was prepared by Soxhlet extraction method and was further subjected to GC-MS to know its bioactive compounds. The in vitro antimicrobial activity assay was tested against five bacteria causing UTI. Klebseilla pneumoniae showed most sensitive followed by Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Enterococcus faecalis in the order. Plant extract showed higher inhibition zone than the positive control used. According to the higher quality of compounds from the GCMS results nine compounds were selected for further in silico studies using GOLD software against four protein targets. The phytoconstituents present in the methanolic extract have the ability to bind at the receptor site of all four targeted proteins. ADMET and TOPKAT studies were also carried out.
Keywords
antimicrobial, plant extract, software and phytoconstituents.
Citation
Sangeeta Devi et al. Bioinformation 18(10): 943-950 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
