Title
A Review on epigenetics alternations in high fat diet induced diabetes [ON HOLD]
Authors
Shyamaladevi Babu1, Jones Eben Raj2,3, Suni Ann Thomas4, KP Bharath5 & Madhan Krishnan*,1
Affiliation
1Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, chengalpattu District, Tamilnadu, India; 2Department of Anatomy, Faculty of Allied Health Sciences, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu, India; 3Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, chengalpattu District, Tamilnadu, India; 4Department of Biochemistry, Al Azhar Medical College Thodupuzha, Kumaramangalam, Kerala, India; 5Department of Anatomy, Madha Dental College and Hospital, Kundrathur, Chennai, Tamilnadu
Shyamaladevi Babu - Email: syamdevi06@gmail.com
Jones Eben Raj - Email: jones.anat@drmgrdu.ac.in & jones2008anatomy@gmail.com
Suni Ann Thomas – Email: sunisarith@gmail.com
Bharath K.P – Email: barathkp_1986@yahoo.com
Madhan Krishnan* - Email: kmadhan91@gmail.com
Article Type
Review
Date
Received June 2, 2022; Revised October 3, 2022; Accepted October 16, 2022, Published October 31, 2022
Abstract
T2DM is complicated, with irreversible risk factors such as age, genetic, race, and ethnicity, as well as reversible risk factors like as food, physical activity, and smoking, with eating habits and sedentary lifestyle being the key contributors for fast growing incidence. Chronic exposure to HFD promotes liver damage, poor glucose homeostasis, hyper insulinemia, late pancreatic β-cell failure to generate insulin due to cell fatigue and resultant hyperglycemia, which are the key hallmarks of T2DM. Metabolic diseases such as T2DM have been linked to epigenetic changes that occur without changes in the DNA sequence, such as cytosine methylation of DNA, histone posttranslational modifications, and microRNA, which provide links between genes and environmental factors such as diet, smoking, and other lifestyle factors. T2DM affects insulin gene expression and beta cell differentiation via both histone modifications and DNA methylation in diabetic islets, which plays a vital role in regulating mitochondrial genes and in diabetes regulation. As a result, we provide existing evidence on epigenetic changes in high fat diet-induced diabetes. Metabolic diseases such as T2DM have been linked to epigenetic changes that occur without changes in the DNA sequence, such as cytosine methylation of DNA, histone posttranslational modifications, and microRNA, which provide links between genes and environmental factors such as diet, smoking, and other lifestyle factors. T2DM affects insulin gene expression and beta cell differentiation via both histone modifications and DNA methylation in diabetic islets, which plays a vital role in regulating mitochondrial genes and in diabetes regulation. In this review, we provide existing evidence on epigenetic changes in high fat diet-induced diabetes.
Keywords
Epigenetics, high fat diet, diabetes, insulin resistance
Citation
Babu et al. Bioinformation 18(10): 916-919 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
