Title

Linking adiponectin expression and kidney dysfunction among Indian patients with and without diabetic nephropathy

Authors

Veluri Ganesh¹, Murugan M^1,*, Veerabhadra Goud GK² & Vijay Kumar Gangannagari³  

Affiliation

¹Department of Biochemistry, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem- 636308, Tamilnadu, India; ²Department of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair - 744104, Andaman and Nicobar Islands, India; ³Department of Microbiology, Akash Institute of Medical Sciences and Research Centre, Bangalore - 562110, Karnataka, India; *Corresponding author   

Email

Veluri Ganesh – E-mail: ganeshbabu370@gmail.com  

Murugan M – E-mail:   avmcbiochemistryedu@gmail.com

Veerabhadra Goud GK – E-mail:  veerabhadrag2006@gmail.com

Vijay Kumar Gangannagari: vijaygtwitter2021@gmail.com

Article Type

Research Article

Date

Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022

Diabetic kidney disease is a common cause of end stage renal disease has a high incidence rate in population with type 2 diabetes mellitus patients. Adiponectin is an adipocytokine shown to strive anti-diabetic, anti-oxidative as well as anti-inflammatory. The present study aimed to determine the serum adiponectin levels in type 2 diabetes mellitus and explore its association with nephropathy. This cross sectional study recruited 90 type 2 diabetes mellitus patients with (n = 60) and without nephropathy (n = 30). Additionally 30 age-, gender, and body mass index matched healthy controls were included. Enzyme linked immunosorbent assay method were used to determine adiponectin concentration. Blood sugars, glycated hemoglobin, body mass index all sounded to be brawny risk factors for nephropathy and microalbumin, e GFR showed a significant association with kidney disease progression in type 2 diabetes mellitus with nephropathy. Both the groups of type 2 diabetes mellitus patients had elevated adiponectin concentrations than controls. Serum adiponectin concentrations were significantly higher in type 2 diabetes mellitus without nephropathy and there was a significant association with nephropathy activity (P<0.0001**). The receiver operating characteristics curve analysis was used to examine the diagnostic performance of adiponectin for nephropathy shown a significant area under the curve 0.998 with sensitivity 100% and specificity 93.33% (P<0.0001**). Hence our study findings concluded that serum adiponectin concentrations considered for the early predictable and prognostic marker for nephropathy.     

Keywords

Adiponectin, HbA1c, Microalbumin, Diabetic Kidney Disease. 

Citation

     Ganesh et al. Bioinformation 18(10): 876-883 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.