Title

Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53

Authors

Yesudass Antony Prabhu¹, Chinnasamy Balalakshmi², Muthu Vijayasarathy³, Kumar Praveen Kumar⁴, Piramanayagam Shanmughavel⁵ & Samiappan Kavitha⁶*    

Affiliation

¹Department of Biochemistry, Rathnavel Subramaniam College of Arts and Science, Bharathiar University, Coimbatore - 641402, India; ²Department of Nanoscience and Technology, Alagappa University, Karaikudi - 630003, India; ³Department of Microbiology, Thiagarajar College of Arts and Science, Madurai, India; ⁴Department of Bioinformatics, Bharathiar University, Coimbatore - 641046, India; ⁵Department of Bioinformatics, Bharathiar University, Coimbatore - 641046, India; ⁶Department of Biochemistry, Rathnavel Subramaniam College of Arts and Science, Bharathiar University, Coimbatore - 641402, India; *Corresponding author: Samiappan Kavitha: kavithabiochemist@yahoo.com & skavitha@rvsgroup.com

Email

Yesudass Antony Prabhu - E-mail: antonybiochemist@gmail.com,

Chinnasamy Balalakshmi - E-mail:samyasribala@gmail.com, https://www.alagappauniversity.ac.in/

Muthu Vijayasarathy - E-mail:vijayasarathymvs@gmail.com, https://www.tcarts.in/

Kumar Praveen Kumar - E-mail:sirajane@gmail.com, https://b-u.ac.in/ 

Piramanayagam Shanmughavel - E-mail: shanmughavel@buc.edu.in; https://b-u.ac.in/

Samiappan Kavitha – E-mail: kavithabiochemist@yahoo.com & skavitha@rvsgroup.com,

Article Type

Research Article

Date

Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022

Extensive research on the mutant P53 protein has identified its pivotal role in anti-apoptosis mechanisms, drug resistance, and cancer progression in OSCC. The mass spectrum revealed the pharmacologically significant bioactive compounds reported for the first time in C cainito. Molecular docking investigation has identified four potential new P53 inhibitors compared with the standard P53 inhibitors. Hence, this analysis reinforces the likelihood of anti-cancer activities in C. cainito leaves.

Keywords

Molecular docking, mutant P53 inhibitors, C. cainito, and OSCC

Citation

Prabhu et al. Bioinformation 18(10): 870-875 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.