Title
Antitumor activity of withaferin-A and propolis in benz (a) pyrene-induced breast cancer
Authors
Thazhathuputhenpurayil Sadhasivan Meghalatha#& Natarajan Muninathan*
Affiliation
Central Research Laboratory, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Kanchipuram Tamil Nadu, India – 631552; *Corresponding author
TS Meghalatha - E-mail: meghalathats@gmail.com
N Muninathan - E-mail: muninathanpappaiya@gmail.com
Article Type
Research Article
Date
Received September 2, 2022; Revised September 30, 2022; Accepted September 30, 2022, Published September 30, 2022
Abstract
Female breast cancer is the leading malignancy surpassing lung cancer recently, and its incidence is continued to rise in many countries. The existing anticancer drugs have limitations like drug resistance and adverse effects leading to poor clinical outcomes. The natural compounds withaferin-A and propolis have been individually reported for their anticancer activity in preclinical models. However, the combined effect of these compounds has not been studied especially in breast cancer models. Therefore, it is of interest to evaluate the effect of Withaferin-A and propolis on Benz(a)pyrene-induced breast cancer. Wistar rats of female gender were treated with saline (normal control), Benz(a)pyrene (disease control), Benz(a)pyrene+ Withaferin-A or Propolis, Benz(a)pyrene+ Withaferin-A+ Propolis. At the end of the treatment, the plasma levels of carcino embryonic antigen (CEA) were measured. We observed a decrease in carcino embryonic antigen (CEA) levels in rats received withaferin-A and propolis combination rather than individual compounds indicating their beneficial role in breast cancer. Results of the present study show that propolis, when combined with withaferin A, exhibits better anti tumor activity than its individual effect in Benz (a) pyrene-induced mammary carcinogenesis.
Keywords
Breast cancer, withaferin-A, propolis, Benz(a)pyrene, carcino embryonic antigen (CEA).
Citation
Meghalatha & Muninathan, Bioinformation 18(9): 841-844 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
