Title

Virus interference in CoViD-19

Authors

Francesco Chiappelli* & Lily Fotovat

Affiliation

Dental Group of Sherman Oaks, CA 91403, USA; *Corresponding author

Email

Francesco Chiappelli - E-mail: Chiappelli.research@gmail.com

Lily Fotovat - E-mail: lilyfotovat@gmail.com

Article Type

Research Article

Date

Received September 15, 2022; Revised September 30, 2022; Accepted September 30, 2022, Published September 30, 2022

Virus interference is one of the oldest concepts in immunology. Recent findings indicate that it may depend on the host’s anti-viral cellular immune surveillance processes, as well as on sequence-specific gene silencing mechanism guided by double-stranded RNA. Other biological events, unrelated to some degree at least from immune-dependent IFN or RNA-dependent viral interference may be at play as well. We discuss these biological mechanisms in the context of of the Systemic Acute Respiratory Syndrome Corona virus2 (SARS-CoV2) virus responsible for Corona Virus Disease 2019 (CoViD-19).

Keywords

Anti-viral immune response, major histocompatibility Complex (MHC), Interferon (IFN), IFN-inducible transmembrane (IFITM) proteins, RNA interference (RNAi), microRNA, Systemic Acute Respiratory Syndrome Corona virus2 (SARS-CoV2), Corona Virus Disease 2019 (CoViD-19), Receptor-Binding Domains (RBD), N-Terminal Domains (NTD) domain

Citation

Chiappelli & Fotovat, Bioinformation 18(9): 768-773 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.