Title
Anti-inflammatory and arthritic activity of zaltoprofen compared to piroxicam in murine models
Authors
Balakrishnan Sadasivam, Ratinder Jhaj, Sunil Kumar, Saman Pathan & Santenna Chenchula*
Affiliation
Department of Pharmacology, All India Institute of Medical Sciences, Saket Nagar, Bhopal - 462020, Madhya Pradesh, India; *Corresponding author
Balakrishnan Sadasivam – E-mail: balakrishnan.pharm@aiimsbhopal.edu.in
Ratinder Jhaj – E-mail: rati.pharm@aiimsbhopal.edu.in
Sunil Kumar – E-mail:sunilgupta.kumar96@gmail.com
Saman Pathan – E-mail: pathan.saman88@gmail.com
Santenna Chenchula – E-mail: csantenna7@gmail.com; Phone: +91 7987220348
Article Type
Research Article
Date
Received July 2, 2022; Revised September 30, 2022; Accepted September 30, 2022, Published September 30, 2022
Abstract
Zaltoprofen, a unique propionic acid group of NSAIDs, works by blocking the enhancing effects of bradykinin along with the COX-2 enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of zaltoprofen versus piroxicam in Murine models. A total of 48 Wister rats (200-250 g) of either sex (24 in each model) were used in the present study. The anti-inflammatory and arthritic potential of zaltoprofen was evaluated and compared by Carrageenan-induced acute inflammation and formalin-induced chronic inflammation. There was a significant inhibition of paw volume (P<0.001) on different time scales with two different doses of the test compound (Zaltoprofen 10 & 20 mg/kg) in the acute inflammation model compared to the negative control (NaCl 10 ml/kg). However, in the chronic inflammation model, zaltoprofen 10 mg/kg and 20 mg/kg doses of the test compound showed a significant reduction in chronic inflammation, comparable to the negative control (NaCl 10 ml/kg), although the potency was lower than the positive control (piroxicam 10 mg/kg) (P 0.05). Thus, zaltoprofen shows significant anti-inflammatory and arthritic effects in both acute and chronic models by inhibiting various inflammatory mediators.
Keywords
Acute Inflammation; Chronic Inflammation; Arthritis; Carrageenan; Zaltoprofen; Piroxicam
Citation
Sadasivam et al. Bioinformation 18(9): 752-757 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
