Title
Effectiveness of bilastine and fexofenadine among allergic Rhinitis patients in Ranchi, Jharkhand, India
Authors
Abha Kumari, Subodh Kumar Paswan, Binod Kumar Sinha, Ritesh Kumar Sinha & Sandeep Kumar*
Affiliation
Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; *Corresponding Author
Abha Kumari - E-mail: drabharims@gmail.com
Subodh Kumar Paswan - E-mail:skpsubodh10@gmail.com
Binod Kumar Sinha - E-mail:binod1959@gmail.com
Ritesh Kumar Sinha - E-mail:Riteshrims@gmail.com
Sandeep Kumar - E-mail:sk16rims@gmail.com
Article Type
Research Article
Date
Received May 2, 2022; Revised June 30, 2022; Accepted June 30, 2022, Published June 30, 2022
Abstract
Allergic rhinitis is a worldwide health problem which impairs quality of life and interferes with daily activities. Untreated allergic rhinitis also carries a significant financial burden for the society. Bilastine, a novel second-generation antihistaminic drug that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. Thus, the aim of our study was to compare the effectiveness of bilastine and fexofenadine in treatment of allergic Rhinitis patients. 104 patients were enrolled who have fulfilled the inclusion criteria for the study from the OPD of Ear, Nose and Throat Department. Patients were divided randomly in two groups A and B. Patients of group A were allowed to take tab Bilastine 20 mg OD whereas, patients of group B were allowed to take tab. Fexofenadine Hydrochloride 120 mg OD orally for two weeks. The baseline Total Nasal Symptom Score (TNSS) were compared between two groups. The study findings showed that the mean TNSS was significantly reduced in our study group. Baseline TNSS was 13.55 and 13.45 in Group A and Group B respectively. Reduction in this parameter first become apparent in the 24 hours and maintained till 2nd week. Bilastine showed significant improvement in quality of life of Allergic rhinitis patients and proved to be more effective than fexofenadine in reducing the TNSS score, when used alone in allergic rhinitis patient.
Keywords
Allergic rhinitis, antihistamine, bilastine, fexofenadine
Citation
Kumari et al. Bioinformation 18(6): 596-599 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
