Title

Insights from the p53 induced TIGAR protein 2 in the glycolytic pathway model

Authors

Mohammad Jahoor Alam

Affiliation

Department of Biology, College of Science, University of Hail, Kingdom of Saudi Arabia; *Corresponding author

Email

Mohammad Jahoor Alam - E-mail: j.alam@uoh.edu.sa;

Article Type

Research Article

Date

Received March 8, 2022; Revised March 31, 2022; Accepted March 31, 2022, Published March 31, 2022

TIGAR is a p53 inducible gene that triggers changes in glycolytic metabolic pathway states. It is known that TIGAR expression lowers the fructose - 2, 6-bisphosphate levels resulting in an inhibition of glycolysis and decrease in intracellular ROS levels. Therefore, it is interesting to document data on p53 induced TIGAR protein 2 in the glycolytic pathway. We describe a two-oscillator model consisting of the p53-Mdm2 network and glycolytic pathway with the TIGAR protein. The numerical simulation of the model shows the suppression of glycolytic oscillation as the level of TIGAR protein increases in agreement with the experimental results reported. Thus, stochastic simulation data helps to understand the realistic behaviour in the pathway.

Keywords

p53, TIGAR, Glycolytic pathway, numerical simulation, Oscillation

Citation

Alam, Bioinformation 18(3): 310-317 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.