Title
FASTK family of genes linked to cancer
Authors
Abilasha Ramasubramanian1,*, A Paramasivam2, & Pratibha Ramani1
Affiliation
1Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Poonamallee High Road, Chennai, Tamilnadu - 600077, India; 2Department of Dental Research Cell- Blue Lab, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Poonamallee High Road, Chennai, Tamilnadu - 600077, India; *Corresponding author – Abilasha Ramasubramanian - Phone no: +919600191071
Abilasha Ramasubramanian - E-mail: abilasha@saveetha.com
Paramasivam A - E-mail: paramasivama.sdc@saveetha.com
Pratibha Ramani - E-mail: pratibaramani@saveetha.com
Article Type
Research Article
Date
Received February 2, 2022; Revised March 25, 2022; Accepted March 31, 2022, Published March 31, 2022
Abstract
Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not only been implicated in tumour progression and invasion but also in increased resistance to chemotherapy proven by their knockdown leading to increased sensitivity to drugs. Thus, this review reports the implication of FASTK proteins in cancer and hence provides a scope to emphasise the role of these proteins in Oral Cancer.
Keywords
FAST, FASTK family, cancer, mitochondrial dysfunction
Citation
Ramasubramanian et al. Bioinformation 18(3): 206-213 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
