Title
Effect of propolis on membrane bound enzymes linked with breast cancer
Authors
Thazhathuputhenpurayil Sadhasivan Meghalatha & Natarajan Muninathan*
Affiliation
Central Research Laboratory, Meenakshi Medical College Hospital and Research Institute, Meenakshi academy of higher education and research (MAHER), Kanchipuram Tamil Nadu, India-631552, *Corresponding author
TS Meghalatha – E-mail: meghalathats@gmail.com
N Muninathan – E-mail: muninathanpappaiya@gmail.com
Article Type
Research Article
Date
Received November 1, 2022; Revised December 20, 2022; Accepted December 31, 2022, Published December 31, 2022
Abstract
According to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enzyme levels. Na+/ K+-ATPase, Mg2+-ATPase, and calcium ATPase enzyme activities were decreased in the erythrocyte membrane and tissues of breast cancer-bearing animals compared with control groups. The levels of enzyme activities were near normal in Propolis treated animals. It was apparent that the beneficial effect of Propolis was primarily exerted during the initiation and post-initiation stage of B(a)p-induced breast carcinogenesis. Overall, the data indicated that Propolis has modulating effects when administered intra-peritoneally on breast cancer-bearing animals.
Keywords
Cancer, ATPase enzymes, Na+/ K+-ATPase, Withaferin-A & Benz (a) Pyrene
Citation
Meghalatha & Muninathan, Bioinformation 18(12): 1192-1195 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
