Title
Severity in schizophrenia patients receiving atypical antipsychotic medications
Authors
Syed Meraj Alam Fatmi1*, Rakesh Koul1, Suruchi Prakash1 & Sheenam Ayub2
Affiliation
1Department of Pharmacology, KD Medical College, Hospital & Research Center, Mathura, India; 2Department of Pediatric and Preventive Dentistry, KD Dental College & Hospital, Mathura; *Corresponding author
Syed Meraj Alam Fatmi –E-mail: me.syedmeraj@gmail.com
Rakesh Koul – E-mail: rakeshkoul386@gmail.com
Suruchi Prakash – E-mail: suruchiprakash21@gmail.com
Sheenam Ayub – E-mail: dr.sheenamayub@gmail.com
Article Type
Research Article
Date
Received November 1, 2022; Revised December 20, 2022; Accepted December 31, 2022, Published December 31, 2022
Abstract
Atypical antipsychotic drugs are nowadays the mainstay of treatment of schizophrenia due to their lesser extrapyramidal symptoms (EPS) as adverse effects. However, these drugs have different profiles of adverse drug reactions (ADRs). Here, the objective of this study was to analyze the probability, occurrences, and more significant involvement of various risk factors. A prospective observational study was carried out on a patient with schizophrenia who has prescribed atypical antipsychotic drugs for their treatment. The probability of the ADR was analyzed by using the Naranjo causality assessment scale. While Glasgow antipsychotic Side effect Scale (GASS) was used to estimate the severity of side effects. Statistical software for social science (SPSS) ver 25; was used for different descriptive statistics and chi-square analysis. A total of 140 patients were included in the study of which the majority (58.57 %) was male. However, atypical antipsychotic drugs were primarily prescribed to the patient as mono therapy (81.43 %). Interestingly, COVID-19 infections were reported as positive in 39.29 % of total patients. Probability assessment of ADRs revealed that most (55 %) were “Probable”. Subsequently, the GASS score was evaluated for severity, the majority (55.71 %) were reported as “Mild”. The statistically significant association between gender and severity of side effects &duration of illness and severity of side effects were found (P>0.5).The Present study aids in knowing the risk factors and improving the management practices of ADR, thereby improving the guidelines in terms of safe clinical approaches for psychiatric patients.
Keywords
Atypical antipsychotic drugs, Adverse drug reactions (ADR), GASS score, Risk factor, Probability
Citation
Fatmi et al. Bioinformation 18(12): 1154-1158 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
