Title
Oxidative stress in breast cancer after chemotherapy
Authors
Sri Phani Tejaswi Pullakanam1*, Murugan Mannangatti2, Ramakrishna Nekkala3, Venkata Madhavi Bellala 4, Ravi Shankar Bellala5 & PayalaVijayalakshmi6
Affiliation
1*Department of Biochemistry, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission‘s Research foundation (VMRF-DU), Pondicherry, Tamilnadu, India; 2Department of Biochemistry, AarupadaiVeedu Medical College & Hospital, Vinayaka Mission‘s Research foundation (VMRF-DU), Pondicherry, Tamilnadu, India; 3Department of Biochemistry, Gayatri Vidya Parishad Institute of Health Care and Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India; 4Department of Pathology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India; 5Clinical Oncology Division, Omega Hospital, Visakhapatnam, Andhra Pradesh, India; 6Department of Microbiology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam-530045, Andhra Pradesh, India; Corresponding author details
Sri Phani Tejaswi Pullakanam - Email: tejaswip223@gmail.com; Phone: +91 8985081842
Murugan Mannangatti - Email: drmurugan@vinayakamissions.com
Ramakrishna Nekkala - Email: dr.ramakrishnanekkala@gmail.com
Venkata Madhavi Bellala - Email: madhavi_bellala@yahoo.co.in
Ravi Shankar Bellala - Email: ravi_bellala@yahoo.co.in
PayalaVijayalakshmi - Email:vpayala@gitam.edu
Article Type
Research Article
Date
Received November 1, 2022; Revised December 20, 2022; Accepted December 31, 2022, Published December 31, 2022
Abstract
It is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containing 30 healthy females of similar age, 30 breast cancer patients without treatment and 30 patients receiving treatment with anticancer combination drugs AC-T. The venous blood samples from both controls and patients were measured for total antioxidant status (TAS), nitric oxide (NO), malondialdehyde, alanine aminotransferase, aspartate aminotransferase, and blood urea, serum creatinine. One-way ANOVA and Tukey-Kramer multiple comparisons post-test were applied as statistical analysis tools through SPPS software version 20.0. P<0.05 was regarded as significant. According to the findings, higher stages of breast cancer were linked to considerable increase in oxidative stress markers during AC-T treatment. The findings of the study revealed that oxidative stress is linked to breast cancer, and that chemotherapy exacerbates this oxidative stress, causing damage to a variety of cellular targets. Monitoring serum oxidative stress markers may aid in the evaluation of chemotherapy effects in breast cancer patients. According to our findings, AC-T chemotherapy will elevate malondialdehyde, a lipid peroxidation marker, and lowers the total antioxidant status.
Keywords
Breast cancer, chemotherapy, malondialdehyde, oxidative stress, total antioxidant status.
Citation
Pullakanam et al. Bioinformation 18(12): 1141-1145 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
