Title

Association of interleukin 6 and uric acid levels in patients with type 2 diabetes mellitus

Authors

Gutlur Nagarajaiah Setty Raghav¹, Somashekar Pallavi², Hareesh Rangaswamaiah ^3,* & Veluri Ganesh⁴

Affiliation

¹Department of General Medicine, Rajarajeswari Medical College and Hospital, Bangalore - 560074, Karnataka, India; ²Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Bangalore - 562110, Karnataka, India; ³Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Bangalore – 562110, Karnataka, India; ⁴Department of Biochemistry, Akash Institute of Medical Sciences and Research Centre, Bangalore – 562110, Karnataka, India; * Corresponding author.        

Email

GN Raghav – E-mail:   rgutlur@gmail.com

S Pallavi - Email: pallavisomashekar93@gmail.com 

R Hareesh - Email: hareesh22578@gmail.com

Veluri Ganesh - Email:  ganeshbabu370@gmail.com

Article Type

Research Article

Date

Received November 1, 2022; Revised December 20, 2022; Accepted December 31, 2022, Published December 31, 2022

Type 2 Diabetes Mellitus (T2DM) patients with coronary artery disease (CAD) coupled with hypertension (HTN) are leading cause of morbidity and mortality. Association of Interleukin 6 and uric acid levels can be used for early detection of CAD in patients with T2DM. This cross sectional study included 120 study participants, were sub grouped into three Group 1: controls (n=30), Group 2: CAD, HTN without T2DM (n=30) and Group 3: CAD, HTN with T2DM (n=30). Basic biochemical, clinical and experimental parameters were analysed and recorded for all the study subjects. The statistical analysis was done by using the SPSS 20.0. Individuals with CAD, HTN with T2DM had higher BMI, weight, SBP, and DBP levels than patients CAD, HTN without diabetes and controls. In CAD, HTN with T2DM study participants has been found to have higher serum levels of inflammatory cytokines like IL-6 and uric acids when compared to CAD, HTN without T2DM and controls. IL6 was significantly positive association with uric acid and negative association with age and HDL. These findings demonstrated a statistically significant positive connection between IL-6, and uric acid concentrations. The identified elevated levels of inflammatory cytokines and uric acids in type 2 diabetic and hypertensive CAD patients may aid in the identification of patients at higher risk.

Keywords

Coronary Artery Disease, Hypertension, T2DM and Interleukin 6

Citation

Raghav et al. Bioinformation 18(12): 1136-1140 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.