Title
Urinary nephrin linked nephropathy in type-2 diabetes mellitus
Authors
Hareesh Rangaswamaiah1, Pallavi Somashekar 2, Raghav Gutlur Nagarajaiah Setty3,*&Veluri Ganesh4
Affiliation
1Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Bangalore - 562110, Karnataka, India; 2Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Bangalore - 562110, Karnataka, India; 3Department of General Medicine, Rajarajeswari Medical College and Hospital, Bangalore –560074, Karnataka, India; 4Department of Biochemistry, Akash Institute of Medical Sciences and Research Centre, Bangalore – 562110, Karnataka, India; * corresponding author.
R Hareesh - Email: hareesh22578@gmail.com
S Pallavi - Email: pallavisomashekar93@gmail.com
GN Raghav - Email: rgutlur@gmail.com
Veluri Ganesh - Email: ganeshbabu370@gmail.com
Article Type
Research Article
Date
Received November 1, 2022; Revised December 20, 2022; Accepted December 31, 2022, Published December 31, 2022
Abstract
Diabetic nephropathy is a one of the risk factor for end stage renal disease in patients with type 2 diabetes mellitus. Urinary micr oalbumin currently marker using for diagnosis of nephropathy in type 2 diabetes mellitus due to its larger variability and less specificity. Urinary nephrin is podocyte protein can be act as a early predictable and prognostic marker than micro albumin for nephropathy in type 2 diabetes mellitus. This case-control prospective observational study included 60 type 2 diabetes mellitus and 30 controls after applying criteria. Basic biochemical, clinical and experimental data were measured and recorded. There was a significantly elevated level of urinary nephrin in type 2 diabetes mellitus patients when compared to controls. The urinary nephrin significantly elevated in normo albuminuria group only when compared to urinary ACR and it is positive association with kidney damage. This study concluded significantly elevated levels of urinary nephrin might be used for early diagnosis and prognostic marker for nephropathy in type 2 diabetes mellitus.
Keywords
Urinary ACR, type 2 diabetes mellitus, nephropathy and nephrin
Citation
Rangaswamaiah et al. Bioinformation 18(12): 1131-1135 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
