Title
Hypolipidemic effect of β-caryophyllene in high fat diet and fructose induced type-2 diabetic adult male rats
Authors
Vadivel Mani1,*, Manikandan Balraj2, Nithya Rajapandian3, Chaitra Jinka4 & Shyamaladevi Babu5*
Affiliation
1Department of Biochemistry, Arunai Medical College & Hospital, Tiruvanamallai- 606603, Tamilnadu, India; 2Department of Physiology, Konaseema Institute of Medical Sciences and Research Foundation, Amalapuram, East Godavari Dt-533201, Andhra Pradesh, India; 3Department of Physiology, Arunai Medical College &Hospital, Tiruvanamallai- 606603, Tamilnadu, India; 4Syngene International Limited, Biocon park, Bangalore, Karnataka, India; 5Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam - 603103, Tamil Nadu, India; *Corresponding author
Manikandan Balraj – E-mail: drmani.ayurveda@gmail.com
Nithya Rajapandiyan - E-mail: nithuran@gmail.com
Chaitra Jinka - E-mail: jinka.chaitra@gmail.com
Shyamaladevi Babu - E-mail: shyamdevi06@gmail.com; dr.shyamaladevi@care.edu.in
Vadivel Mani - E-mail: velvdmvel5@gmail.com
Article Type
Research Article
Date
Received November 1, 2022; Revised November 29, 2022; Accepted November 30, 2022, Published November 30, 2022
Abstract
Skeletal muscle is responsible for the majority of insulin-stimulated whole-body glucose elimination, under normal circumstances. High dietary fat consumption increases stored fat mass and is a major risk factor for metabolic disorders. The conventional pharmacological treatments are associated with many adverse side effects and high rates of secondary failure which lead to an increasing demand for natural products with anti-diabetic activity and lesser side effects. β-Caryophyllene is a naturally occurring sequiterpene that may be found in cannabis and a range of culinary herbs and spices. It contains antioxidant, anti-inflammatory, and anti-lipidemic effects, among others. However, the effect of β-Caryophyllene on glucose absorption and oxidation, is yet unknown. Hence, the current study was intended to investigate the anti-diabetic impact of β-Caryophyllene in type-2 diabetes caused by a high-fat diet. To evaluate its anti-diabetic efficacy, high fat diet and fructose-induced type-2 diabetic rats were administered an effective dosage of β-Caryophyllene (200 mg/kg b.wt, orally for 30 days). The treatment of diabetes-induced rats with β-Caryophyllene restored the altered levels of blood glucose, serum insulin as well as lipid parameters. Our findings show that β-caryophyllene improves glycemia control by alleviating dyslipidemia in type-2 diabetic rats. From the present findings, it is evident that β-caryophyllene can be used as an anti-diabetic drug.
Keywords
Type 2 diabetes, β-caryophyllene, high fat diet, skeletal muscle, glucose uptake, glycogen
Citation
Mani et al. Bioinformation 18(11): 1087-1091 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
