Title

In vitro antimicrobial and cytotoxic activity of Neem and Kirata herbal formulation mediated Silver nanoparticles

Authors

R Rebekah¹, SP Saravana Dinesh¹, B Nivethigaa^1* & S Rajeshkumar²

Affiliation

¹Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical sciences(SIMATS), Saveetha University, Chennai – 77; ²Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai -77, India; *Corresponding author

Email

R Rebekah - E-mail: 152108001.sdc@saveetha.com

SP Saravana Dinesh - E-mail: drsaravanadinesh@gmail.com

B Nivethigaa - E-mail: nivethigaab.sdc@saveetha.com

S Rajeshkumar - E-mail: rajeshkumars.sdc@saveetha.com

Article Type

Research Article

Date

Received November 1, 2022; Revised November 29, 2022; Accepted November 30, 2022, Published November 30, 2022

Silver nanoparticles (AgNPs) gain great interest among noble metal nanoparticles due to their broad applications in medicine, dentistry, drug delivery, tissue and tumour imaging, biolabeling, and biosensing. The antibacterial, antifungal, antiviral, and antiparasitic activity of AgNPs is well documented in the literature. This study aimed to determine the antimicrobial and cytotoxic activity of Neem and Kirata herbal formulation-mediated silver nanoparticles against oral biofilm. The green synthesis of Neem and Kirata herbal formulation-mediated silver nanoparticles was done. The antimicrobial action against the strains of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, and Streptococcus mutans were assessed. The results showed that the newly formulated nanoparticle had effective anti-microbial properties and decreased cytotoxic properties which make it advantageous for clinical applications and treatment modalities. It showed great potential for the nanoparticle in decreasing the bacterial effects and cytotoxic nature thereby providing future scope for clinical application in preventing oral biofilm formation and its deleterious effects.

Keywords

Nanoparticles, AgNp, neem extract, kirata, green synthesis, antimicrobial property, cytotoxicity.

Citation

     Rebekah et al. Bioinformation 18(11): 1069-1074 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.