Title

GC-MS profiling and bioactivity prediction of compounds from Momordica charantia L. extract

Authors

¹Pinak Pani Nath Choudhury* & ²Sudip Choudhury

Affiliation

¹Department of Zoology, S. S. College, Hailakandi, Assam – 788151; ²Center for Soft Matter, Department of Chemistry, Assam University, Silchar, 788011;

Email

*Corresponding author: E-mail address: pinaknath@sscollegehkd.ac.in; Tel: +91 3844222409; Fax: +91 3844222409.

Article Type

Research Article

Date

Received September 2, 2022; Revised October 3, 2022; Accepted October 6, 2022, Published October 31, 2022

Momordica species are vegetable crops, belonging to the family of Cucurbitaceae. For the present study plant samples of Momordica charantia were collected from different parts of Barak Valley of Assam, India. Hyphenated technique Gas Chromatography-Mass Spectroscopy (GC-MS) of the chromatographically separated components of the plant extract was performed to identify some of the principles. All the isolated compounds exhibited notable interaction with the enzyme Bone morphogenic protein upon in silico screening. All the compounds were screened in silico for toxicity and then docked with the target enzyme individually. It was found that these compounds are interacting with the target enzyme and is able to inhibit the enzyme activity more efficiently as compared to the reference ligand.

Keywords

bitter melon, phytochemical, fruit tissue, ethyl acetate, extract, GCMS

Citation

Choudhury & Choudhury, Bioinformation 18(10): 1009-1015 (2022)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.