Title
Safety and physiologic effects of intranasal midazolam and nitrous oxide inhalation based sedation in children visiting Saveetha Dental College and Hospitals, India
Authors
Neethu Ann Preethy* & Sujatha Somasundaram
Affiliation
Saveetha Dental College,Saveetha Institute Of Medical and Technical Sciences,Chennai,Tamil Nadu,India.*Corresponding author
Neethu Ann Preethy- jesusisgreat.neethuann@gmail.com.Telephone: +91 9715528833; Sujatha Somasundaram: drsujatha.sdc865@gmail.com; Telephone: +91 9941012929
Article Type
Research Article
Date
Received October 28, 2021; Revised November 14, 2021; Accepted November 14, 2021, Published January 31, 2022
Abstract
A large number of patients avoid dental care due to anxiety. Various techniques are available for behaviour related management. Therefore, safety and physiologic effects of intranasal midazolam and nitrous oxide inhalation based sedation in children aged 4 to 8 years visiting Saveetha Dental College and Hospitals, India is of interest. 35 anxious patients aged 4 to 8 years were included in the study. The patient received either intranasal midazolam/nitrous oxide in the first visit and vice versa at the second visit. The onset of sedation, recovery time and procedure duration were recorded using a timer. Physiological parameters were recorded using a monitor. Safety scale was used for assessing prevalence of adverse reactions. There was no significant difference between the groups in safety scale scores, recovery time and procedure duration. Midazolam group showed a statistically significant faster onset of sedation and a statistically significant increase in heart rate at four recorded time-points. All the vitals were within the physiological limits. Thus, intranasal midazolamis a safe alternative to nitrous-oxide sedation in completing the intended dental treatment while managing the anxious children in dental clinic.
Keywords
midazolam, nitrous oxide, conscious sedation, safety, children
Citation
Preethy & Somasundaram, Bioinformation 18(1): 26-35 (2022)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
