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Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt



Vadivel Mani1, Manikandan Balraj2, Gayathri Venktsan3, Jagatheesh Soundrapandiyan4, Revathi Kasthuri4, Anandhi Danavel5,* & Shyamaladevi Babu6



1Department of Biochemistry, Arunai Medical College & Hospital, Tiruvanamallai-606603, Tamilnadu, India; 2Department of Physiology, Konaseema Institute of Medical sciences and research foundation, Amalapuram, East Godavari Dt-533201, Andhra Pradesh, India; 3Department of Physiology, Krishnadevaraya college of dental sciences and Hospital, Bangalore, Karanadakha, India; 4Department of Research, Meenakshi Academy of Higher Education, Chennai-600078, Tamilnadu, India; 5Department of biochemistry, Meenakshi Ammal Dental College & Hospital, Chennai-600095, Tamilnadu, India; 6Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India; *Corresponding author



Anandhi Danavel - Email ID: thivyeshwar@gmail.com


Article Type

Research Article



Received October 1, 2021; Revised October 18, 2021; Accepted October 18, 2021, Published November 30, 2021



Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment. Hence, novel problem-solving approaches for assessing early metabolic diseases, notably insulin resistance, are urgently needed. Screening of natural compounds for drug discovery to combat diabetes is common in modern medical research and development. Therefore, it is of interest to document the molecular docking analysis data of beta-Caryophyllene, a naturally occurring sequiterpene with the downstream insulin signaling molecules such as IRS-1, cSrc and Akt for the management of type-2 diabetes. The molecular docking analysis data of beta-caryophyllene with the insulin downstream signaling molecules such as IRS-1, cSrc and Akt reveals its ability and further studies are needed to elucidate its complete mechanism of action against type-2 diabetes.



Diabetes mellitus; insulin resistance; Beta-Caryophyllene; molecular docking analysis; IRS-1; Akt



Mani et al. Bioinformation 17(11): 916-920 (2021)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.