Title
Codon usage signatures in Sabia and Chapare for host adaptation
Authors
Himani Malhotra1,* & Arvind Kumar2,*
Affiliation
Department of Biotechnology1, Department of Biochemistry2, School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar Delhi G.T. Road, Phagwara, Punjab, INDIA -144411. *Corresponding author
Arvind Kumar – E-mail: arvind.19345@lpu.co.in; Phone:+91-9815289975; Himani Malhotra - E-mail: himani.11814490@lpu.in,Tel:+91-9463133277
Article Type
Research Article
Date
Received October 5, 2021; Revised October 16, 2021; Accepted October 16, 2021, Published October 31, 2021
Abstract
Sabia and Chapare viruses in the Arenavirus family cause viral hemorrhagic fever among humans with a fatality rate of 30% with no treatment models. Therefore, it is of interest to document the codon usage, amino acid patterns and associated factors influencing the observed variations in Sabia and Chapare viruses for host adaptation. Multivariate statistical analysis revealed compositional constraint and host selection pressure influencing the viral codon usage patterns. These data suggests the codon usage signatures in Sabia and Chapare viruses for host adaptation in the human host implying its role in the rapid progression of the infection. Dinucleotides UpG and CpA were noted to be over-represented among the Sabia, Chapare viruses and human genomes. Strong restraint from the usage of CpG dinucleotides among viruses is linked with the molecular mimicry of the human immune system. Thus, the data reported from this study help in understanding the mechanism of viral adaptation inside the host genome for further consideration in drug discovery.
Keywords
Sabia virus; Chapare virus; Homo sapiens; codon usage; dinucleotides
Citation
Malhotra & Kumar, Bioinformation 17(10): 891-898 (2021)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
