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Biochemical predictors for Sars-Cov-2 severity



Ezhil Gurusamy1,*, S Mahalakshmi1, Gurumoorthy Kaarthikeyan2, K Ramadevi1, Parkavi
Arumugam2 & MS Gayathri3



1Institute of Biochemistry, Madras Medical College, RGGGH, Chennai, India; 2Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai Ė 77; 3Institute of Biochemistry, Stanley Medical College, Chennai; *Corresponding author; Ezhil Gurusamy - Mobile: +91 7299505966;



E-mail: ezhil2085@gmail.com


Article Type

Research Article



Received August 28, 2021; Revised September 21, 2021; Accepted September 21, 2021, Published September 30, 2021



It is of interest to assess the inflammatory marker profile in SARS-CoV-2 patients and to correlate the levels of systemic inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (NLR), C-Reactive Protein CRP, Ferritin, Creatine kinase (CK), Lactate dehydrogenase (LDH) and liver function analytes total serum proteins, albumin, total bilirubin, direct bilirubin, alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with the severity of SARS-CoV-2 infections. A total of 1000 COVID-19 positive patientís data were collected. Laboratory assessments consisted of NLR (neutrophil-lymphocyte ratio) by cell counter, C Reactive Protein (CRP) by immunoturbidimetry, Ferritin by electrochemiluminescence (ECLIA) and Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total Bilirubin, Direct Bilirubin, Total Protein and Albumin by spectrophotometry. The mean plasma CRP levels, NLR, ferritin, CK and LDH levels were higher in severe cases than in non-severe cases, and the difference was statistically significant (p<0.05). All liver function tests such as the total and direct bilirubin, AST, ALT, ALP, total protein and albumin were higher in severe patients than nonsevere patients and the difference was statistically significant (p<0.05). Data indicate that NLR, CRP, Ferritin, CK, LDH and liver function analytes have a crucial role as prognostic markers for SARS-CoV-2 infections and hence should be routinely recommended for risk assessment and stratification of the patients to reduce the associated morbidity and mortality.



Biochemical predictors, severity, Sars-Cov-2



Gurusamy et al. Bioinformation 17(9): 834-839 (2021)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.