Title

Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells

Authors

Chella Perumal Palanisamy¹, Sivakumar Pethanan² Gopinath Gurulingam Vincent², Karthigeyan Murugesan², Ananthavalli Ramachandran², Ramu Sivanandam³ & Mani Panagal^4*

Affiliation

¹State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China; ³Department of zoology, Arumugam Pillai Seethai Ammal College, Tiruppathur, Tamil Nadu, India; ²Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu-614001, India; ⁴Department of Biotechnology, Annai College of Arts and Science, Kovilacheri, Tamil Nadu 612503, India

Email

^*Corresponding author - Panagal Mani - Email: mani.panagal@yahoo.com

Article Type

Research Article

Date

Received June 30, 2021; Revised July 19, 2021; Accepted July 19, 2021, Published August 31, 2021

It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor
receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced
in C. trifolia treated A2780 cell lines for further consideration as a chemotherapeutic agents.

Keywords

Cayratia trifolia; CXCR4 and HER2 protein expression, Metastatic signalling, Anti-ovarian cancer activity

Citation

Palanisamy et al. Bioinformation 17(8): 710-714 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.