Title

Combinational therapeutics to combat cancer

Authors

Ahmed Al Otaibi¹, Subuhi Sherwani², Eida Mohammed Alshammari¹, Salma Ahmed Al-Zahrani¹, Wahid Ali Khan³, Abdulmohsen Khalaf Dhahi Alsukaibi¹, Sourabh Dwivedi⁴, Shahper Nazeer Khan⁵ & Mohd Wajid Ali Khan1,6,*

Affiliation

¹Department of Chemistry, College of Sciences, University of Ha段l, Ha段l-2440, Saudi Arabia; ²Department of Biology, College of Sciences, University of Ha段l, Ha段l-2440, Saudi Arabia; ³Department of Clinical Biochemistry,College of Medicine, King Khalid University, Abha-62529, Saudi Arabia; ⁴Department of Applied Physics, Aligarh Muslim University, Aligarh-202002, U.P., India; ⁵Interdisciplinary Nanotechnology Centre, Aligarh Muslim University, Aligarh-202002, U.P., India; ⁶Molecular Diagnostic and Personalised Therapeutics Unit, University of Ha段l, Ha段l-2440, Saudi Arabia

Email

Mohd Wajid Ali Khan- Email; wajidkhan11@gmail.com; mw.khan@uoh.edu.sa; ^*Corresponding author

Article Type

Research Article

Date

Received July 6, 2021; Revised July 12, 2021; Accepted July 12, 2021, Published July 31, 2021

Mono-therapeutics is rarely effective as a treatment option, which limits the survival of patients in advanced grade aggressive cancers. Combinational therapeutics (multiple drugs for multiple targets) to combat cancer is gaining momentum in recent years. Hence, it is of interest to document known data for combinational therapeutics in cancer treatment. An amalgamation of therapeutic agents enhances the efficacy and potency of the therapy. Combinational therapy can potentially target multiple pathways that are necessary for the cancer cells to proliferate, and/or target molecules, which may help cancer to become more aggressive and metastasize. In this review, we discuss combinational therapeutics, which include human T cells in combinations with biologically active anti-cancer molecules, which synergistically may produce promising combinational therapeutics.

Keywords

biologically active molecules, T cells, cancer, combinational therapeutics, synergistic

Citation

Al Otaibi et al. Bioinformation 17(7): 673-679 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.