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Molecular docking analysis of COX-2 with compounds from Piper longum



Dhirendra Tripathi1, Sravanthi Koora2, K Satyanarayana3, S Saleem Basha4,* & Selvaraj Jayaraman5



1Department of Otorhinolaryngology, Government Medical College, Shivpuri, Shivpuri - 473638; 2Department of Pharmacology, Government Medical College Siddipet 502103, Siddipet, Telangana; 3Department of Biochemistry, Government Medical College Siddipet, Siddipet 502103, Telangana India; 4Department of Medical Biochemistry, School of Medicine, Haramaya university, Harar Campus, Ethiopia; 5Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai-600 077, India



Corresponding author*; Dr. S. Saleem Basha; Email: saleem.basha09@gmail.com


Article Type

Research Article



Received April 25, 2021; Revised May 27, 2021; Accepted May 28, 2021, Published June 30, 2021



Piper longum (Indian long pepper) is known for its use as an anti inflammatory agent in Indian Ayurvedic System of medicine. Therefore, it is of interest to document the molecular docking analysis of compounds from Piper longum with COX-2 using the Autodock Vina PyRx tool.
Molecular docking results show that asarinine, sesamine, fargesin, and piperlonguminine have optimal binding energy of 10, 10, -9.5 and 9.4 Kcal/mol, respectively for further consideration.



Anti-inflammatory compunds, COX-2, Piper longum, molecular docking



Tirupathi et al. Bioinformation 17(6): 623-627 (2021)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.