Title
Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-α in the context of inflammation
Authors
Lavanya Prathap1, Selvaraj Jayaraman*, 2, Anitha Roy3, Preetha Santhakumar4, M. Jeevitha5
Affiliation
1Department of Anatomy, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India. Email id: drpreeth.homeo@gmail.com; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 3Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 4Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 5Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India.
*Corresponding author; J. Selvaraj - Phone: +91 8608566435. Email Id: jselvaendo@gmail.com
Article Type
Research Article
Date
Received December 18, 2020; Revised February 20, 2021; Accepted February 24, 2021, Published February 28, 2021
Abstract
Inflammatory is cascade process triggered by pro-inflammatory cytokines and anti-inflammatory. In the present study anti-inflammatory activity of Stachydrine and Sakuranetin were studied against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed the good binding with selected target proteins. Compared to Sakuranetin, the Stachydrine have lowest binding energy and good hydrogen bond interactions. Hence results of study indicated that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6.
Keywords
IL-6, TNF-α, inflammation, molecular docking
Citation
Prathap et al. Bioinformation 17(2): 363-368 (2021)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
