Title

Molecular docking analysis of furfural and isoginkgetin with heme oxygenase I and PPARγ

Authors

Preetha Santhakumar1*, Lavanya Prathap2, Anitha Roy3, Selvaraj Jayaraman4, M. Jeevitha5

Affiliation

1Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 2Department of Anatomy, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 3Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 4Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India; 5Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India
 

Email

*Corresponding author: Preetha Santhakumar1*, - Phone: +91 8608566435. Email Id: drpreeth.homeo@gmail.com

Article Type

Research Article

Date

Received December 18, 2020; Revised February 20, 2021; Accepted February 24, 2021, Published February 28, 2021

Inflammatory is cascade process triggered by pro-inflammatory cytokines and anti-inflammatory. In the present study anti-inflammatory activity of Stachydrine and Sakuranetin were studied against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed the good binding with selected target proteins. Compared to Sakuranetin, the Stachydrine have lowest binding energy and good hydrogen bond interactions. Hence results of study indicated that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6.

Keywords

Furfural; isoginkgetin; anti-inflammation; molecular docking.

Citation

Santhakumar et al. Bioinformation 17(2): 356-362 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.