Title |
Molecular docking of alkaloid compounds with the matrix metalloproteinase 2 |
Authors |
JH Shazia Fathima1, Jayaraman Selvaraj J2,*, Venkatacalam Sivabalan3, Umapathy Vidhya Rekha4,Rajagopal Ponnulakshmi5, Veeraraghavan Vishnupriya2, Malathi Kullappan6, Radhika nalinakumari Sreekandan7, Surapaneni Krishna Mohan8
|
Affiliation |
1Department
of Oral and Maxillofacial Pathology, Ragas Dental College and
Hospitals, Chennai, India; 2Department of
Biochemistry,Saveetha Dental College and Hospitals, Saveetha
Institute of Medical and Technical Sciences, Saveetha University,
Chennai - 600 077, India; 3Department of Biochemistry,
KSR Institute of Dental Sciences and Research, Thiruchengodu-637215,
India; 4Department of Public Health Dentistry, Sree
Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100,
India; 5Central Research Laboratory, Meenakshi Academy of
Higher Education and Research (Deemed to be University), Chennai-600
078, India; 6Department of Research, Panimalar Medical
College Hospital & Research Institute, Varadharajapuram,
Poonamallee, Chennai - 600 123, India; 7Department of
Clinical Skills & Simulation, Panimalar Medical College Hospital &
Research Institute, Varadharajapuram, Poonamallee, Chennai - 600
123, India;8Department of Biochemistry and Department of
Clinical Skills & Simulation, Department of Research, Panimalar
Medical College Hospital & Research Institute, Varadharajapuram,
Poonamallee, Chennai - 600 123; 9DBT-BIF Centre, PG &
Research Department of Biotechnology
|
|
Dr. Jayaraman Selvaraj - E-mail:
jselvaendo@gmail.com
|
Article Type |
Research Article
|
Date |
Received December 29, 2020; Revised
December 31, 2020; Accepted January 26, 2020, Published January 31,
2021
|
Abstract |
Matrix metalloproteinase protein-2 (MMP-2) is linked to the human oral squamous cell carcinoma. Therefore, it is of interest to design new inhibitors for MMP-2 to combat the disease. Thus, we document the molecular docking features of Aristolochic acid, Cryptopleurine, Epipodophyllotoxin, and Fagaronine with MMP-2 for further consideration.
|
Keywords |
MMP-2; OSCC; alkaloids; molecular
docking.
|
Citation |
Fathima et al. Bioinformation 17(1): 206-211 (2021)
|
Edited by |
P Kangueane
|
ISSN |
0973-2063
|
Publisher |
|
License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
|
|