Molecular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus

HOME | PDF |

Title	Molecular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus
Authors	Jayaraman Selvaraj^1,*, Umapathy Vidhya Rekha², Shazia Fathima JH³, Venkatacalam Sivabalan⁴, Rajagopal Ponnulakshmi⁵, Veeraraghavan Vishnupriya¹, Malathi Kullappan⁶, Radhika nalinakumari Sreekandan⁷ Surapaneni Krishna Mohan⁸
Affiliation	¹Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ²Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; ³Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India; ⁴Department of Biochemistry, KSR Institute of Dental Sciences and Research, Thiruchengodu-637215, India; ⁵Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; ⁶Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ⁷Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ⁸Department of Biochemistry and Department of Clinical Skills & Simulation, Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123
Email	Dr. Jayaraman Selvaraj - Email: jselvaendo@gmail.com;
Article Type	Research Article
Date	Received December 29, 2020; Revised January 26, 2021; Accepted January 29, 2021, Published January 31, 2021
Abstract	It is of interest to document the moelcular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus. Hence, we report the binding features of rutin, Luteolin, Salvianolic acid A, Rosmarinic acid and p-Coumaric acid with the target protein SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) for further consideration.
Keywords	SARS-CoV-2, RdRp, Plectranthus amboinicus, molecular docking
Citation	Selvaraj et al. 17(1): Bioinformation 167-170 (2021)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.