Inference of link between diabetes, obesity, and thyroid dysfunction in data at a Saudi Arabian clinic

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Title	Inference of link between diabetes, obesity, and thyroid dysfunction in data at a Saudi Arabian clinic
Authors	Alsamghan S Awad^1,*, Faisal Mubarak Mastour Alshahrni², Fatmah Salem Alhawyan³, Eisa Yazeed Ghazwani⁴, Mohammed Yahia Alasmary⁵, Abdulaziz saad Alshahrani⁶, Muhammad Abubaker A Tobaiqi⁷, Sultan Saeed Mohammed Alshahrani⁸, Shahad Saleh Abdullah Alghamdi⁹, Semat Talal Hassan Bakri¹⁰ & Adil Ali Ayed¹¹
Affiliation	¹Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, KSA-61421; ²Family Medicine Consultants Armed Forces Hospitals Southern Region, Khamis Mushait, Aseer, Kingdom of Saudi Arabia; ³Diabetes and Metabolism, Armed Forces Hospitals Southern Region, Khamis Mushait, Aseer, Kingdom of Saudi Arabia; ⁴Family and Palliative Medicine, Department of Family & Community Medicine, Faculty of Medicine, Najran University, Najran, Kingdom of Saudi Arabia; ⁵Department of Medicine, Faculty of Medicine, Najran University, Najran, Kingdom of Saudi Arabia; ⁶Department of Medicine, Faculty of Medicine, Najran University, Najran, Kingdom of Saudi Arabia; ⁷Family Medicine, Department of Family and Community Medicine, Taibah University, Kingdom of Saudi Arabia; ⁸College of Medicine, King Khalid University, Abha, KSA-61421;⁹College of Medicine, King Khalid University, Abha, KSA-61421;¹⁰Intern Doctor, college of Medicine, King Khalid University, Abha, KSA-61421;¹¹King Khalid University, Abha, KSA- 61421.
Email	Awad Saeed Alsamghan - E-mail: awadsg42@gmail.com; Faisal Mubarak Mastour Alshahrni - E-mail: dr.faisal2010@live.com; Fatmah Salem Alhawyan - E-mail: Dr-alhawayan@hotmail.com; Eisa Yazeed Ghazwani - E-mail: dreisaa@gmail.com; Mohammed Yahia Alasmary - E-mail: myalasmary@nu.edu.sa; Abdulaziz shad Alshahrani - E-mail: dr.abdulaziz2015@gmail.com; Muhammad Abubaker A Tobaiqi - Email:mtobegi@taibahu.edu.sa; Sultan Saeed Mohammed Alshahrani - E-mail: sultansaeed2019@gmail.com; Shahad Saleh Abdullah Alghamdi - E-mail: shahad.ghamdi95@gmail.com; Semat Talal Hassan Bakri - E-mail: sematbakri.95@gmail.com; Ayed, Adil Ali - E-mail: adil@kku.edu.sa; Asad Saeed – E-mail: awadsg42@gmail.com
Article Type	Research Article
Date	Received October 29, 2020; Revised December 31, 2020; Accepted January 26, 2020, Published January 31, 2021
Abstract	The clinical link among diabetes, obesity, and thyroid dysfunction is of interest. Hence, medical records of 601 patients with diabetes, obesity, and thyroid dysfunctions at the Abha Specialist Center and Military Diabetic Endocrine Center we used in this analysis. Approximately 28% of diabetic patients had thyroid dysfunction, and 12.4% were vitamin D deficient. The patients with thyroid dysfunction had significantly elevated triglyceride levels compared to the patients without thyroid dysfunction (173.6 vs. 128. p=0.009). Vitamin D deficient obese patients were significantly younger (33.99±10.69 vs. 43.68±14.42; p<0.001) and had significantly lower levels of HbA1c (5.73±1.16 vs. 6.83±2.08; p=0.014) and lower systolic BP (120.26±11.75 vs. 124.58±13.63; p=0.049) than non-vitamin D deficient obese patients. Vitamin D deficient thyroid patients had significantly lower diastolic BP (71.4±9.9 vs. 74.9±9.7; p=0.040) and higher HbA1c (8.7±3.6 vs. 6.4±1.7; p=0.003) in comparison to non-vitamin D deficient thyroid patients. Hence, analysis of metabolic disorders in these patients will help combat complications in these cases.
Keywords	Diabetes, Thyroid disorder, vitamin D deficiency
Citation	Alsamghan et al. Bioinformation 17(1): 119-125 (2021)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.