Title
Aberrations in SMAD family of genes among HNSCC patients
Authors
E. Thariny, A.S. Smiline Girija, A. Paramasivam & J. Vijayashree Priyadharsini
Affiliation
Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Indi; Corresponding author*
Dr. J. Vijayashree Priyadharsini, E-mail: vijayashreej.sdc@saveetha.com; T. Lakshmi - E-mail: lakshmi@saveetha.com
Article Type
Research Article
Date
Received June 17, 2021; Revised September 27, 2021; Accepted September 27, 2021, Published December 31, 2021
Abstract
Head and neck cancer is a debilitating disease with several etiological factors. One of the main etiologies to be noticed is the alteration, which is either caused by genetic or environmental factors. Therefore, it is of interest to assess the effect of genetic alterations, especially the non-synonymous mutations of the SMAD gene family and its possible association with HNSCC. Data shows a significant novel mutation in the SMAD gene family in association with head and neck squamous cell carcinoma (HNSCC), which would aid in better diagnosis and treatment planning for cancer.
Keywords
Cancer, mutation, SMAD gene, genetic alteration, head and neck, pathogenicity
Citation
Thariny et al. Bioinformation 17(12): 1113-1119 (2021)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
