Title
Molecular docking analysis of azithromycin and hydroxychloroquine with spike surface glycoprotein of SARS-CoV-2
Authors
Jitender Singh, Deepti Malik & Ashvinder Raina*
Affiliation
Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India. Pin-160012
Ashvinder Raina - Email: drashvinder@gmail.com, *Corresponding author
Article Type
Research Article
Date
Received October 22, 2020; Revised November 6, 2020; Accepted November 6, 2020; Published January 31, 2021
Abstract
Millions of people are affected by COVID-19 since the last quarter of 2019. Treatment using hydroxychloroquine (HCQ) as monotherapy in combination with azithromycin (HCQ-AZ) were administered at several clinical centres to patients tested positive to the virus across continents. Therefore, it is of interest to document the molecular docking analysis data of azithromycin and hydroxychloroquine drug with the spike surface glycoprotein of novel COVID-19. Thus, we report the molecular modelling docking based structural binding features of HCQ-AZ with the spike surface glycoprotein of COVID-19 for further evaluation in this regard.
Keywords
Drugs; pharmacokinetics; binding pocket; molecular docking; structure activity relationship.
Citation
Raina et al. Bioinformation 17(1): 11-22 (2021)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
