Title
In vitro and molecular docking studies of an antiinflammatory scaffold with human peroxiredoxin 5 and tyrosine kinase receptor
Authors
R. Bharathi & N. Santhi*
Affiliation
Research and development centre, Bharathiar university, Coimbatore, 641046, India; Department Of Chemistry, Govt Arts College, C. Mutlur, Chidambaram 608102, India
*Corresponding author; N Santhi – E-mail: nsanthigac@gmail.com
Article Type
Research Article
Date
Received October 2, 2020; Revised October 24, 2020; Accepted October 24, 2020; Published November 30, 2021
Abstract
A new series of 4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile (4a-h) compounds were synthesized and evaluated for in-vitro anti-inflammatory activities. The spectral (IR, NMR) and elemental analyses data of the product indicated the formation of new pyrazoles 4a-h. Compound 4e exhibited potent anti-inflammatory property with 85.45 % inhibitions. This value was compared with standard diclofenac sodium. This data is explained using molecular docking analysis of receptor-ligand binding. These results demonstrated that pyrazole derivatives are potential inhibitors of Human Peroxiredoxin 5 and Tyrosine kinase receptor in the treatment of inflammation related illness.
Keywords
in vitro anti-inflammatory, pyrazoline, docking, autodock
Citation
Bharathi & Santhi, Bioinformation 16(11): 929-936 (2020)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
