Title

Molecular docking analysis of the BRCA1 protein with compounds from Justica adhatoda L

Authors

Selvaraj Jayaraman¹, Vishnupriya Veeraraghavan², Radhika Nalinakumari Sreekandan³, Surapaneni Krishna Mohan⁴, Sumetha Suga Deiva Suga⁵, Devakumar Kamaraj⁶, Sonaimuthu Mohandoss⁷, Sravanthi Koora^8*

Affiliation

^1,2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 3Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123; ⁴Department of Biochemistry and Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123; ⁵Department of Microbiology, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123; ⁶Department of Pharmacology, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123; ⁷School of Chemical Engineering, Yeungnam University, Gyeongsan, Gyeongbuk-do, 38541, Republic of Korea; ⁸Department of Pharmacology, Government Medical College Siddipet, Siddipet-502 103, Telangana, India

Email

*Corresponding Author - Sravanthi Koora, Email: sravanthi.koora.87@gmail.com

Article Type

Research Article

Date

Received September 11, 2020; Revised October 21, 2020; Accepted October 21, 2020; Published November 30, 2020

BRCA1 is a human tumour suppression gene. Therefore, it is of interest to document the Molecular docking analysis data of the BRCA1 protein with compounds from Justica adhatoda L (adhatoda). We report that Amrinone, Hexadecanoic acid, Pyrazinamide & Vasicinone have acceptable binding features with the BRCA1 protein for further consideration.

Keywords

BRCA1, Justica adhatoda L, Molecular docking

Citation

Jayaraman et al. Bioinformation 16(11): 888-892 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.