Title
Protein targets in the red complex organisms binding with an herbal compound silymarin
Authors
Nadhirah Faiz, Keshaav Krishnaa
Pothapur, V. Vishnu Priya*, R. Gayathri, J. Vijayashree
Priyadharsini
Affiliation
Saveetha Dental College and Hospitals, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha University Chennai 600077, Tamilnadu, India;
R. Gayathri - Email ID: gayathri.sdc@saveetha.com;
V. Vishnu Priya - Email ID:
vishnupriya@saveetha.com; *Corresponding author
Article Type
Research Article
Date
Submitted on July 9, 2020; Revision September 8, 2020; Accepted September 9, 2020; Published October 31, 2020
Abstract
Periodontitis is attributed to the dental biofilm formation caused by various microbial changes that occurs in the biofilm. Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound silymarin. We report a list of potential proteins having optimal drug like binding features with the herbal agent silymarin for further consideration. We used the STITCH v.5 pipeline using VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound silymarin were thus identified and reported for further consideration.
Keywords
Protein targets, red complex organisms, silymarin
Citation
Faiz et al. Bioinformation 16(10): 759-764 (2020)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
