Title

Molecular docking analysis of human JAK2 with compounds from tomatoes

Authors

Umapathy Vidhya Rekha¹, M. Anita¹, S. Bhuminathan² & K. Sadhana¹

Affiliation

¹Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600 100, India; ²Department of Prosthodontics, Sree Balaji Dental College and Hospital, BIHER, Pallikaranai, Chennai 600 100, India

Email

Dr. Umapathy Vidhya Rekha - Email: drvidhyarekha@gmail.com; Corresponding author

Article Type

Research Article

Date

Received May 30, 2020; Revised June 15, 2020; Accepted September 4, 2020; Published October 31, 2020

Janus kinase 2 (JAK2) is a tyrosine kinase receptor that belongs to the JAK family kinases is linked to oral cancer. We describe the molecular binding analysis of JAK2 with 23 compounds from tomotoes. Docking data shows five compounds (rutin, qucertin, narigenin, chlrogenia acid & kaempferol) with optimal binding features with JAK2 for further consideration.

Keywords

Lycopersicon esculentum, JAK2, Oral Cancer, Molecular docking

Citation

Rekha et al. Bioinformation 16(10): 742-747 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.