Title

Molecular docking analysis of DNA ligase from Staphylococcus aureus with identical polysaccharides

Authors

Anitha Roy¹, Aneymol Varikalam Sleeba², Rini Joy³, Ponnulakshmi Rajagopal⁴

Affiliation

¹Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India; ²Department of Microbiology, St. Xavier’s College for Women, Aluva, Kerala-683101, India; ³Department of Oral Medicine and Radiology, SRM Dental College and Hospitals, Ramapuram, Chennai - 600089, Tamil Nadu, India; ⁴Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be Universiy) Chennai-600 078, India

Email

*Corresponding author: Dr. Anitha Roy - Email: anitharoy2015@gmail.com

Article Type

Research Article

Date

Submitted on July 31, 2020; Revision August 13, 2020; Accepted August 13, 2020; Published September 30, 2020

Staphylococcus aureus has been recognized as an important human pathogen for more than 100 years. DNA ligase is the main protein responsible for the replication of S. aureus. DNA ligase was selected as successive target to control the replication mechanism. The antibacterial activity of polysaccharide is known. Therefore, it is of interest to study the activity of Polysaccharide analogues against DNA ligase in S. aureus using molecular docking analysis. We report ten analogues using scoring parameters with best two analogues as potential drug candidate for the combat of S. aureus infection.

Keywords

S. aureus, DNA ligase, Polysaccharide, Molecular docking

Citation

Roy et al. Bioinformation 16(9): 719-724 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.