Title

Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant

Authors

Jayaraman Selvaraj¹, Hussain Sardar², Veeraraghavan Vishnupriya³, Janardhana Papayya Balakrishna⁴, Surapaneni Krishna Mohan⁵, Rajamanickam Pon Nivedha⁶, Periyasamy Vijayalakshmi⁷, Rajagopal Ponnulakshmi^8*

Affiliation

¹Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ²Department of Biotechnology, Government Science College, Chitradurga-577501, Karnataka, India; ³Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ⁴Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, India; ⁵Department of Biochemistry and Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ⁶Exonn Biosciences, Ticel Bio Park, Chennai-600 0113, India; ⁷PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy- 620002, Tamil Nadu, India; ⁸Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; Dr. Rajagopal Ponnulakshmi – E-mail: ramgslaks@gmail.com; *Corresponding author:

Email

Dr. Rajagopal Ponnulakshmi – E-mail: ramgslaks@gmail.com; *Corresponding author:

Article Type

Research Article

Date

Submitted on March 30, 2020; Revision June 9, 2020; Accepted June 11, 2020; Published July 31, 2020

Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.

Keywords

Alzheimer's disease, Protein Network analysis, Gymnema sylvestre, Molecular docking

Citation

Selvaraj et al. Bioinformation 16(7): 561-566 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.