Title
Controlled drug release for inflammatory bowel disease (IBD)
Authors
D Asha1, S Jeganath2, G Bupesh3,5,*, UK Sahoo5, M Bhaskar4, K Pandian6
Affiliation
1Department of Microbiology, Saastra College of Pharmaceutical Education and Research, Nellore, AP, India 2Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology And Advanced Studies (VISTAS), Pallavaram, Chennai-600117, India. 3Research and Development Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital (SBMCH), BIHER, Chennai-600044, India; 4Department of Forestry, Mizoram University, Aizawl, Mizoram -796004; 5Department of Forest Science, School of Science, Nagaland University (Central), Lumami, Zenheboto, Nagaland-798627, India; 6Department of Inorganic Chemistry, University Madras, Chennai, India
Dr. S. Jeganath - Email Id: jeganaths@gmail.com;
Dr. G. Bupesh - Contact no: +91
8012405965; Email Id: bupeshgiri55@gmail.com; *Corresponding author
Article Type
Research Article
Date
Received January 1, 2020; Revised May 31, 2020; Accepted June 4, 2020; Published July 31, 2020
Abstract
Controlled drug release in formulation is an important area of research. Formulations using crospovidone as super-disintegrants to achieve immediate release once it reaches the ileo-cecal region is relevant. The Eudragit L30D pH dependent polymer that allows drug release after a lag time of 4-5 hrs to achieve desired lag time and drug release from current drug delivery system is critical. Pre-formulation to investigate drug-polymer interaction is essential. The linear correlation between the predicted and actual values for all the batches of optimization with high correlation coefficient r-value is shown. Therefore, the designed formulation is promising for ileo-cecal targeted pulsatile drug delivery system in the management of Crohn’s disease.
Keywords
Budesonide Crohn’s disease, lag time, crospovidone, 32 factorial designs.
Citation
Asha et al. Bioinformation 16(7): 513-524 (2020)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
